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- Title
Melanocortin-4 Receptor Gene Polymorphisms in Obese Patients.
- Authors
Yurtcu, Erkan; Yilmaz, Akin; Ozkurt, Zubeyde; Kolukisa, Emine; Yilmaz, Murat; Keles, Hatice; Ergun, Mehmet Ali; Yetkin, Ilhan; Menevse, Adnan
- Abstract
Obesity is a complex disease caused by both genetics and environmental factors. Melanocortin-4 receptor ( MC4R) (MIM 155541) gene polymorphisms were reported to be the cause of monogenic obesity in humans. We studied three polymorphisms (Val50Met, Val103Ile, and Ser58Cys) and a mutation (Asn274Ser) of the MC4R gene in 203 obese patients and in 110 healthy subjects in the Turkish population. A high incidence of Val103Ile and Val50Met polymorphisms as well as the Asn274Ser mutation was found in the obese patients, whereas no significant correlation was found regarding the Ser58Cys polymorphism. We conclude that there is a concordance between the polymorphisms (Val103Ile, Val50Met, Ser58Cys) that were first studied in the Turkish population with obesity.
- Subjects
OBESITY; GENETIC disorders; ENVIRONMENTALLY induced diseases; GENETIC polymorphisms; METABOLIC disorders
- Publication
Biochemical Genetics, 2009, Vol 47, Issue 3/4, p295
- ISSN
0006-2928
- Publication type
Article
- DOI
10.1007/s10528-009-9228-4