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- Title
Mapping of ACE2 binding site on SARS-CoV-2 spike protein S1: docking study with peptides.
- Authors
Kuznetsov, Aleksei; Järv, Jaak
- Abstract
Among different approaches to control the COVID-19 disease, there is clear interest to develop inhibitors which block the virus interaction with the host cells and through this simple mechanism could facilitate developing medication. In this report, interaction of the virus SARS- CoV-2 spike protein S1 binding site with potential antiviral peptide ligands is analysed computationally. The peptides are derived from the binding domain of the angiotensinconverting enzyme 2, which is the receptor site for this virus. These calculations reveal that although shortening of these peptides from the N terminus and C terminus reduces their docking energy on the S1 binding site, there is still a number of peptides which effectively bind to the binding site on the SARS CoV2 spike protein S1, and thus can be used as leads for further optimization of the inhibitory effect. Finally, this may open new perspectives for working out treatments against the virus infection.
- Subjects
BINDING sites; SIGNAL recognition particle receptor; SARS-CoV-2; VIRUS diseases; PROTEIN binding
- Publication
Proceedings of the Estonian Academy of Sciences, 2020, Vol 69, Issue 3, p228
- ISSN
1736-6046
- Publication type
Article
- DOI
10.3176/proc.2020.3.06