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- Title
Early Postnatal Changes of Bone Turnover Biomarkers in Very Low-Birth-Weight Neonates-The Effect of Two Parenteral Lipid Emulsions with Different Polyunsaturated Fatty Acid Content: A Randomized Double-Blind Study.
- Authors
Papandreou, Panos; Agakidis, Charalampos; Scouroliakou, Maria; Karagiozoglou‐Lampoudi, Thomai; Kaliora, Adriana; Kalogeropoulos, Nick; Siahanidou, Tania; Karagiozoglou-Lampoudi, Thomai
- Abstract
<bold>Background: </bold>ω-3 polyunsaturated fatty acids (n-3 PUFAs) are reported to have beneficial effect on bone mineral density. This study aimed to evaluate early changes of bone turnover biomarkers in very low-birth-weight (VLBW) neonates and the effect of 2 parenteral lipid emulsions (PLEs) with different PUFA composition.<bold>Methods: </bold>This is a randomized double-blind study with parallel design. VLBW neonates (n = 66) receiving parenteral nutrition (PN)>70% of daily energy requirements for >14 days were assigned into 2 groups that were prescribed soybean oil-based (n = 35) and n-3-enriched PLE (n = 31), respectively. Osteoprotegerin (OPG), soluble receptor activator of nuclear factor-kB ligand (sRANKL), osteocalcin (OC), interleukin-6 (enzyme-linked immunoblot assay kits), Ca, and P plasma levels were assessed before PLE implementation (T1) and on day 20 of life (T2).<bold>Results: </bold>In the total population, sRANKL and OC significantly increased, whereas OPG and the OPG/sRANKL ratio decreased from T1 to T2. Within each group, T1-to-T2 changes of OC were significant in both groups, whereas those of OPG/sRANKL were significant only in the soybean-based group. Multiple regressions showed an independent effect of group allocation on OPG change. Significant associations were observed between PN duration and sRANKL change (negatively), n-6/n-3 and OC changes (positively), and OPG and sRANKL changes (positively).<bold>Conclusions: </bold>A high bone-turnover rate in VLBW neonates with predominance of bone resorption is confirmed. The lower rate of OPG/sRANKL reduction in the n-3-enriched PLE group indicates that n-3 PUFA-enriched PLEs may help to attenuate early bone loss in VLBW neonates.
- Subjects
UNSATURATED fatty acids; BONES; NEWBORN infants; BONE density; EMULSIONS; RESEARCH; RESEARCH methodology; EVALUATION research; MEDICAL cooperation; LOW birth weight; COMPARATIVE studies; RANDOMIZED controlled trials; BONE remodeling; BLIND experiment; PARENTERAL feeding
- Publication
JPEN Journal of Parenteral & Enteral Nutrition, 2020, Vol 44, Issue 2, p361
- ISSN
0148-6071
- Publication type
journal article
- DOI
10.1002/jpen.1533