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- Title
Longer-term effects of cardiac resynchronization therapy on mortality in heart failure [the CArdiac REsynchronization-Heart Failure (CARE-HF) trial extension phase].
- Authors
Cleland, John G.F.; Daubert, Jean-Claude; Erdmann, Erland; Freemantle, Nick; Gras, Daniel; Kappenberger, Lukas; Tavazzi, Luigi
- Abstract
Aims The CArdiac REsynchronization-Heart Failure study randomized patients with left ventricular ejection fraction ≤35%, markers of cardiac dyssynchrony, and persistent moderate or severe symptoms of heart failure despite pharmacological therapy, to implantation of a cardiac resynchronization therapy (CRT) device or not. The main study observed substantial benefits on morbidity and mortality during a mean follow-up of 29.4 months [median 29.6, interquartile range (IQR) 23.6–34.6]. Prior to study closure, an extension phase lasting a further 8 months (allowing time for data analysis and presentation) was declared during which cross-over was discouraged.
- Publication
European Heart Journal, 2006, Vol 27, Issue 16, p1928
- ISSN
0195-668X
- Publication type
Article