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- Title
Role of D-dimer in the Development of Portal Vein Thrombosis in Liver Cirrhosis: A Meta-analysis.
- Authors
Junna Dai; Xingshun Qi; Hongyu Li; Xiaozhong Guo
- Abstract
Background and Aims: A meta-analysis was performed to explore the role of the D-dimer in the development of portal vein thrombosis (PVT) in liver cirrhosis. Methods: All papers were searched via PubMed, EMBASE, China National Knowledge Infrastructure, Wan Fang, and VIP databases. A standardized mean difference (SMD) with 95% confidence interval (CI) was pooled. Results: Overall, 284 studies were initially identified, of which 21 were included. Cirrhotic patients with PVT had a significantly higher D-dimer concentration than those without PVT (pooledSMD = 1.249,95%CI = 0.740-1.758). After the portal hypertension-related surgery, cirrhotic patients with PVT had a similar preoperative D-dimer concentration to those without PVT (pooled SMD = 0.820, 95%CI = -0.122-0.286), but a higher postoperative value of D-dimer concentration than those without PVT (pooled SMD = 2.505, 95%CI = 0.975-4.036). Notably, the D-dimer concentration at the 1st postoperative day was similar between cirrhotic patients with and without PVT (pooled SMD = 0.137,95%CI = -0.827-1.101), but that at the 7th post-operative day was higher in cirrhotic patients with PVT than in those without PVT (pooled SMD = 1.224, 95%CI = 0.277-2.171). Conclusion: D-dimer might be regarded as a diagnostic marker for PVT in liver cirrhosis. In addition, postoperative D-dimer testing is worthwhile for the diagnosis of PVT after portal hypertension-related surgery.
- Subjects
CONFIDENCE intervals; DATABASES; MEDICAL information storage &; retrieval systems; CIRRHOSIS of the liver; MEDLINE; META-analysis; ONLINE information services; PORTAL vein; PREVENTIVE health services; THROMBOSIS; SYSTEMATIC reviews; FIBRIN fibrinogen degradation products; DATA analysis software; DISEASE complications
- Publication
Saudi Journal of Gastroenterology, 2015, Vol 21, Issue 3, p165
- ISSN
1319-3767
- Publication type
Article
- DOI
10.4103/1319-3767.157567