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- Title
Influence of Aging on Outcomes of Sacubitril/Valsartan in Hypertensive Patients with Heart Failure: A Multicenter Retrospective Study.
- Authors
Chengchun Zuo; Xiaoye Li; Yingyun Guan; Linlin Fan; Jing Li; Dan Tian; Can Chen; Xiaoyu Li; Zhichun Gu; Chi Zhang; Xiaolan Bian; Qianzhou Lv
- Abstract
Background: The aim of this study was to investigate the influence of aging on the effectiveness and tolerance of sacubitril/valsartan (sac/val) among hypertensive patients complicated with heart failure in a real-world setting. Methods: This multicenter, retrospective study included patients (=18 years old) admitted with a diagnosis of hypertension and heart failure, starting sac/val therapy between January 2020 and December 2021 from 3 medical centers. Patients were grouped by the cutoff age of 65 years. Outcomes were collected 31-365 days after the initiation of sac/val and were compared in a matched cohort after 1: 1 propensity score matching (PSM). Results: A total of 794 patients were finally analyzed. Blood pressure and cardiac functions improved significantly compared with values at baseline. There were 269 patients in each cohort (<65 years and ≥65 years) after PSM. After PSM, the incidence of hyperuricemia and hypotension in the elderly patients (≥65 years) was significantly higher than in those <65 years of age. Kaplan-Meier estimate suggested that the cumulative incidence of new or recurrent cardiovascular events increased significantly at the age of ≥65 years after the point of 3 months (log-rank P = .00087). Conclusion: Sac/val benefited patients in both cohorts by improving blood pressure and cardiac function. Elderly patients (=65 years) were susceptible to hypotension, low diastolic blood pressure, hyperuricemia, and underwent cardiac-related readmissions more frequently.
- Subjects
HYPERTENSION; HEART failure patients; HEART failure; ENTRESTO; DIASTOLIC blood pressure; BLOOD pressure
- Publication
Anatolian Journal of Cardiology / Anadolu Kardiyoloji Dergisi, 2024, Vol 28, Issue 4, p194
- ISSN
2149-2263
- Publication type
Article
- DOI
10.14744/AnatolJCardiol.2023.3857