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- Title
SYNTHESIS OF BIOLOGICALLY ACTIVE XANTHENE, CHROMENE, THIAZOLE, THIOPHENE, PYRAZOLE, AND ISOXAZOLE DERIVATIVES FROM CAMPHOR.
- Authors
Alwan, Ensaf Sultan; Mohareb, Rafat Milad
- Abstract
Xanthene, chromene, thiazole, thiophene, pyrazole, and isoxazole derivatives were synthesized from camphor-D monoterpene using multi-component reactions. Camphor has anti-bacterial, anti-fungal and antiinflammatory properties. It is also used to mitigate pain, treat skin diseases, and improve respiratory functions. In this research, we focus on the effectiveness of the produced compounds from the biologically active camphor. The produced compounds were formed according to various reactions such as a Knoevenagel condensation, Michael adduct, Gewald reaction, a nucleophilic attack, substitution, addition, elimination and cyclization reactions. Furthermore, the novel produced compounds have been tested towards the six cancer cell lines namely A549, MKN-45, U87MG, HT-29, H460 and SMMC-772. Compounds 5, 11, 15b, 16, 25b and 27b displayed the highest inhibitions compounds toward the mentioned cancer cell lines. In addition, compounds 3, 13, 15a, 22a, 27a and 28 showed moderate inhibitory effects against the cancer cell lines.
- Subjects
ISOXAZOLES; BIOACTIVE compounds; XANTHENE; THIOPHENES; PYRAZOLES; ELIMINATION reactions
- Publication
Bulletin of the Chemical Society of Ethiopia, 2023, Vol 37, Issue 6, p1539
- ISSN
1011-3924
- Publication type
Article
- DOI
10.4314/bcse.v37i6.18