We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A Novel Therapeutic Combination for Neuroblastoma.
- Authors
Zage, Peter E.; Lizhi Zeng; Palla, Shana; Fang, Wendy; Nilsson, Monique B.; Heymach, John V.; Zweidler-McKay, Patrick A.
- Abstract
The article presents a study on the combination of vandetanib and 13-cis-retinoic acid (CRA) for the treatment of neuroblastoma tumor. An evaluation on the effects of vandetanib on rearranged during transfection (RET) phosphorylation and on survivability of human neuroblastoma cell lines was conducted. Results of the study showed that vandetanib causes neuroblastoma tumor cell death and decreases tumor growth and combination of vandetanib and CRA is more effective against neuroblastoma tumor.
- Subjects
VASCULAR endothelial growth factors; ISOTRETINOIN; NEUROBLASTOMA; CELL lines; CELL death; TUMOR growth prevention; THERAPEUTICS
- Publication
Cancer (0008543X), 2010, Vol 116, Issue 10, p2465
- ISSN
0008-543X
- Publication type
Article
- DOI
10.1002/cncr.25017