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- Title
Evidence for two independent prostate cancer risk–associated loci in the HNF1B gene at 17q12.
- Authors
Jielin Sun; Siqun Lilly Zheng; Wiklund, Fredrik; Isaacs, Sarah D.; Purcell, Lina D.; Zhengrong Gao; Fang-Chi Hsu; Seong-Tae Kim; Wennuan Liu; Yi Zhu; Stattin, Pär; Adami, Hans-Olov; Wiley, Kathleen E.; Dimitrov, Latchezar; Jishan Sun; Tao Li; Turner, Aubrey R.; Adams, Tamara S.; Adolfsson, Jan; Johansson, Jan-Erik
- Abstract
We carried out a fine-mapping study in the HNF1B gene at 17q12 in two study populations and identified a second locus associated with prostate cancer risk, ∼26 kb centromeric to the first known locus (rs4430796); these loci are separated by a recombination hot spot. We confirmed the association with a SNP in the second locus (rs11649743) in five additional populations, with P = 1.7 × 10−9 for an allelic test of the seven studies combined. The association at each SNP remained significant after adjustment for the other SNP.
- Subjects
PROSTATE cancer; GENETIC recombination; CHROMOSOMES; GENETIC engineering; GENETICS
- Publication
Nature Genetics, 2008, Vol 40, Issue 10, p1153
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng.214