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- Title
The effects of anti-CD3 antibodies on the development of T-cell receptor αβ<sup>+</sup> lymphocytes in embryonic thymus organ cultures.
- Authors
Owen, J. J. T.; Owen, M. J.; Williams, G. T.; Kingston, P.; Jenkinsson, E. J.
- Abstract
Cells expressing the γδ T-cell receptor in association with CD3 molecules appear in the embryonic thymus before αβ CD3+ cells. We have added anti-CD3 antibodies to organ cultures of mouse thymus removed from embryos before any CD3+ cells have appeared, with the aim of blocking the function of the latter as they are generated in the cultures. Our results show that these antibodies affect the maturation of precursors of αβ+ cells so that D-J but not V-D-J β-chain arrangements predominate. In contrast, full length α gene transcripts are produced. These results are compatible with the view that the early population of γδ CD3+ cells plays a role in the maturation of the αβ+ population.
- Subjects
THYMUS; ANIMAL models in research; CD antigens; T cell receptors; IMMUNOGLOBULINS; LYMPHOCYTES
- Publication
Immunology, 1988, Vol 63, Issue 4, p639
- ISSN
0019-2805
- Publication type
Article