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- Title
Influence of ablative margin on local tumor progression and survival in patients with HCC ≤4 cm after laser ablation.
- Authors
Francica G; Petrolati A; Di Stasio E; Pacella S; Stasi R; Pacella CM; Francica, Giampiero; Petrolati, Alesssandra; Di Stasio, Enrico; Pacella, Sara; Stasi, Roberto; Pacella, Claudio Maurizio
- Abstract
<bold>Background: </bold>Ablation of the normal hepatic parenchyma surrounding the tumor (ablative margin [AM]) is necessary to prevent local tumor progression. <bold>Purpose: </bold>To assess the prognostic value of the ablative margin in patients with HCC ≤4 cm treated with US-guided laser ablation. <bold>Material and Methods: </bold>A cohort of 116 patients (53 women and 63 men, age range 42-82 years) with 132 HCC nodules ≤4 cm completely ablated by US-guided laser ablation was retrospectively analyzed. Rates of local tumor progression were compared using different ablative margin cut-offs (≥2.5, 5.0, 7.5, and 10.0 mm). Survival probability curves were obtained with the Kaplan-Meier method. <bold>Results: </bold>The mean period of follow-up was 42 months (range 3-114 months). Local tumor progression was identified in 24 out of 132 lesions (18%), with an average time to progression of 24 months (range 6-36 months). A significant difference in local tumor progression was observed only if the ablative margin was ≥7.5 mm (7% vs. 23%, P = 0.020). Survival curves of patients with or without an ablative margin ≥7.5 mm were not different (P = 0.665; mean survival time 43.8 ± 3.1 and 46.8 ± 6.1 for an AM < or ≥7.5 mm, respectively). <bold>Conclusion: </bold>An ablative margin ≥7.5 mm turned out to be useful in preventing local tumor progression but did not affect long-term survival in patients with HCC ≤4 cm treated with laser ablation.
- Publication
Acta Radiologica, 2012, Vol 53, Issue 4, p394
- ISSN
0284-1851
- Publication type
journal article
- DOI
10.1258/ar.2012.110471