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- Title
Is urinary 1-hydroxypyrene a valid biomarker for exposure to air pollution in outdoor workers? A meta-analysis.
- Authors
Ciarrocca, Manuela; Rosati, Maria Valeria; Tomei, Francesco; Capozzella, Assuntina; Andreozzi, Giorgia; Tomei, Gianfranco; Bacaloni, Alessandro; Casale, Teodorico; Andrè, Jean Claude; Fioravanti, Mario; Cuartas, Maria Fernanda; Caciari, Tiziana
- Abstract
The aim of this study was to evaluate the usefulness and specificity of urinary 1-hydroxypyrene (1-OHPu) as a biomarker of the exposure from urban pollution to polycyclic aromatic hydrocarbons (PAHs) among outdoor workers in a meta-analysis. Our meta-analysis was performed according to standard methods, and the results show that the concentrations of 1-OHPu tend to be higher in exposed workers than in unexposed workers (if we exclude two highly heterogeneous articles), in exposed non-smokers than in unexposed non-smokers and in exposed than in unexposed workers who were carriers of the CYP1A1 genotype and in those with the glutathione-S-transferase M1 (−)genotype. These genotypes enhance the effect of exposure, particularly in non-smokers. Smoking reduces the differences between exposed and unexposed subjects. In conclusion, our results suggest that the use of the 1-OHPu biomarker appears to be reliable for studying occupational exposure to PAHs from urban pollution, as long as environmental and behavioural factors are considered.
- Subjects
PHYSIOLOGICAL effects of air pollution; PHYSIOLOGICAL effects of polycyclic aromatic hydrocarbons; URBAN pollution; BIOMARKERS; META-analysis; THRESHOLD limit values (Industrial toxicology)
- Publication
Journal of Exposure Science & Environmental Epidemiology, 2014, Vol 24, Issue 1, p17
- ISSN
1559-0631
- Publication type
Article
- DOI
10.1038/jes.2012.111