We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Synthesis and Structure Activity Relationship of Some Indole Derivatives as Potential Anti-inflammatory Agents.
- Authors
Fatahala, Samar S.; Khedr, Mohammed A.; Mohamed, Mossad S.
- Abstract
A series of fused pyrroles were synthesized and tested for their in vivo anti-inflammatory activity. Among 14 examined derivatives, 5 derivatives (1b-e, g and 5b), showed a promising anti-inflammatory activity equivalent to reference anti- inflammatory drugs (indomethacin and ibuprofen). A molecular docking study was conducted to interpret the biological activities of the tested compounds. The docking results were complementary with the phase of the biological survey and confirmed the biological effects.
- Subjects
HETEROCYCLIC compounds; CHEMICAL synthesis; ANTINEOPLASTIC agents; INDOMETHACIN; ANTIARTHRITIC agents
- Publication
Acta Chimica Slovenica, 2017, Vol 64, Issue 4, p865
- ISSN
1318-0207
- Publication type
Article
- DOI
10.17344/acsi.2017.3481