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- Title
Synthesis and Cyclization Reactions with Pyrazolopyrimidinyl Keto-esters and their Enzymaic Activity.
- Authors
Abd el Gawaad Awas, Mohamed Abdel Hamid
- Abstract
Ethyl 2,4-dioxo-4-(4-oxo-1-phenyl-1,4-dihydo-5H-pyrazolo[3,4-d]pyrimidin-5-yl)butanoate, ethyl 5-(4-oxo-1-phenyl- 1,4-dihydro-5H-pyrazolo[3,4-d]pyrimidin-5-yl)-1H-pyrazole-3-carboxylate and their acid hydrazide derivatives have been prepared and reacted with hydrazines, ortho-phenylenediamine, triethyl orthoformate, carbon disulfide and thiosemicarbazides in order to obtain some new 5-substituted pyrazolopyrimidin-4-ones as pyrazolines, isoxazolines, imidazoles, pyrazolotriazines, thiadiazoles and triazoles. All newly prepared compounds revealed the potent effect on increasing reactivity of cellobiase. Structures of new compounds were established upon their elemental analysis, IR, 1H NMR and mass fragmentation spectra.
- Subjects
RING formation (Chemistry); ESTERS; PYRIMIDINES; TRIAZOLES; CARBON disulfide
- Publication
Acta Chimica Slovenica, 2008, Vol 55, Issue 3, p492
- ISSN
1318-0207
- Publication type
Article