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- Title
Nanomaterial-Driven Precision Immunomodulation: A New Paradigm in Therapeutic Interventions.
- Authors
Aljabali, Alaa A. A.; Obeid, Mohammad A.; Gammoh, Omar; El-Tanani, Mohamed; Mishra, Vijay; Mishra, Yachana; Kapre, Sumedha; Srivatsa Palakurthi, Sushesh; Hassan, Sk. Sarif; Nawn, Debaleena; Lundstrom, Kenneth; Hromić-Jahjefendić, Altijana; Serrano-Aroca, Ángel; Redwan, Elrashdy M.; Uversky, Vladimir N.; Tambuwala, Murtaza M.
- Abstract
Simple Summary: This review assesses the integration of nanotechnology and immunotherapy, with a specific focus on the utilization of nanomaterials to modulate the immune system in conditions such as cancer and autoimmunity. Liposomes, polymers, and inorganic nanoparticles (NPs) are versatile nanomaterials capable of effectively transporting immunomodulatory molecules. Their interactions with immune cells have contributed to the development of checkpoint inhibitors, improved cancer vaccines, and the optimization of adoptive cell therapies. These approaches enable the fine-tuning of immune responses with minimal adverse effects. Positioned at the forefront of the convergence of nanotechnology and immunology, nanomaterial-based platforms have the potential to revolutionize patient-centered immunotherapy. These systems are used in the transformative era of disease management by prioritizing safety, personalization, and compliance with regulations. Immunotherapy is a rapidly advancing field of research in the treatment of conditions such as cancer and autoimmunity. Nanomaterials can be designed for immune system manipulation, with precise targeted delivery and improved immunomodulatory efficacy. Here, we elaborate on various strategies using nanomaterials, including liposomes, polymers, and inorganic NPs, and discuss their detailed design intricacies, mechanisms, and applications, including the current regulatory issues. This type of nanomaterial design for targeting specific immune cells or tissues and controlling release kinetics could push current technological frontiers and provide new and innovative solutions for immune-related disorders and diseases without off-target effects. These materials enable targeted interactions with immune cells, thereby enhancing the effectiveness of checkpoint inhibitors, cancer vaccines, and adoptive cell therapies. Moreover, they allow for fine-tuning of immune responses while minimizing side effects. At the intersection of nanotechnology and immunology, nanomaterial-based platforms have immense potential to revolutionize patient-centered immunotherapy and reshape disease management. By prioritizing safety, customization, and compliance with regulatory standards, these systems can make significant contributions to precision medicine, thereby significantly impacting the healthcare landscape.
- Subjects
TUMOR treatment; NANOSTRUCTURES; POLYMERS; PATIENT safety; IMMUNOTHERAPY; IMMUNE system; TREATMENT effectiveness; CANCER vaccines; CELLULAR therapy; PARADIGMS (Social sciences); IMMUNE checkpoint inhibitors; INDIVIDUALIZED medicine; ARTIFICIAL membranes; NANOPARTICLES
- Publication
Cancers, 2024, Vol 16, Issue 11, p2030
- ISSN
2072-6694
- Publication type
Article
- DOI
10.3390/cancers16112030