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- Title
Time Course of Postoperative Recovery of N-Acetyl-Aspartate in Temporal Lobe Epilepsy.
- Authors
Serles, W.; Li, L.M.; Antel, S.B.; Cendes, F.; Gotman, J.; Olivier, A.; Andermann, F.; Dubeau, F.; Arnold, D.L.
- Abstract
Purpose: To assess the time course of increases in N-acetyl-aspartate/creatine (NAA/Cr), which can be measured using proton MR spectroscopic imaging ( 1 H-MRSI), in patients with intractable nonlesional temporal lobe epilepsy (TLE) after successful epilepsy surgery. Methods: We performed pre- and postoperative 1 H-MRSI in 16 seizure-free (SF) patients and 16 not seizure-free (NSF) TLE patients. We calculated a mixed-design analysis of variance (ANOVA) between SF and NSF groups, ipsi- and contra-lateral to the side of operation, and pre- and postoperative NAA/Cr measurements. We applied nonlinear regression be-tween pre- and postoperative NAA/Cr differences and the time interval between 1 H-MRSI scans to fit a negative exponential model to NAA recovery. Results: Mixed-design ANOVA revealed that (a) postopera-tive NAA/Cr was significantly higher in SF than in NSF...
- Subjects
TEMPORAL lobe epilepsy; EPILEPSY; BRAIN surgery
- Publication
Epilepsia (Series 4), 2001, Vol 42, Issue 2, p190
- ISSN
0013-9580
- Publication type
Article
- DOI
10.1046/j.1528-1157.2001.4220190.x