We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Factors affecting number of lymph nodes harvested and the impact of examining a minimum of 12 lymph nodes in stage I-III colorectal cancer patients: a retrospective single institution cohort study of 1167 consecutive patients.
- Authors
Hsiang-Lin Tsai; Ching-Wen Huang; Yung-Sung Yeh; Cheng-Jen Ma; Chao-Wen Chen; Chien-Yu Lu; Ming-Yii Huang; I-Ping Yang; Jaw-Yuan Wang; Tsai, Hsiang-Lin; Huang, Ching-Wen; Yeh, Yung-Sung; Ma, Cheng-Jen; Chen, Chao-Wen; Lu, Chien-Yu; Huang, Ming-Yii; Yang, I-Ping; Wang, Jaw-Yuan
- Abstract
<bold>Background: </bold>To identify factors affecting the harvest of lymph nodes (LNs) and to investigate the association between examining a minimum of 12 LNs and clinical outcomes in stage I-III colorectal cancer (CRC) patients.<bold>Methods: </bold>The clinicopathologic features and the number of examined LNs for 1167 stage I-III CRC patients were analyzed to identify factors affecting the number of LNs harvested and the correlations between clinical outcomes and high harvests (≧12 LNs) and low harvests (<12 LNs).<bold>Results: </bold>A multivariate analysis showed that age (P = 0.007), tumor size (P = 0.030), and higher T stage (P = 0.001) were independent factors affecting the examinations of LNs in colon cancer and that tumor size (P = 0.015) was the only independent factor in rectal cancer. Patients with low harvests had poorer overall survival with stage II and stage III CRC (stage II: P < 0.0001; III: P = 0.001) and poorer disease-free survival for stages I-III (stage I: P = 0.023; II: P < 0.0001; III: P = 0.001).<bold>Conclusions: </bold>The factors influencing nodal harvest are multifactorial, and an adequate number of examined LNs (≧12) is associated with a survival benefit. Removal of at least 12 LNs will determine the lymph node status reliably.
- Subjects
LYMPH node cancer; COLON cancer patients; COHORT analysis; RECTAL cancer; PROGRESSION-free survival; MULTIVARIATE analysis; COLON tumors; SURGICAL excision; LYMPH nodes; LYMPH node surgery; METASTASIS; PROGNOSIS; RECTUM tumors; TUMOR classification; RETROSPECTIVE studies
- Publication
BMC Surgery, 2016, Vol 16, p1
- ISSN
1471-2482
- Publication type
journal article
- DOI
10.1186/s12893-016-0132-7