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- Title
Caspase-2 is resistant to inhibition by inhibitor of apoptosis proteins (IAPs) and can activate caspase-7.
- Authors
Ho, Po-ki; Jabbour, Anissa M.; Ekert, Paul G.; Hawkins, Christine J.
- Abstract
Caspases are a family of cysteine proteases with roles in cytokine maturation or apoptosis. Caspase-2 was the first pro-apoptotic caspase identified, but its functions in apoptotic signal transduction are still being elucidated. This study examined the regulation of the activity of caspase-2 using recombinant proteins and a yeast-based system. Our data suggest that for human caspase-2 to be active its large and small subunits must be separated. For maximal activity its prodomain must also be removed. Consistent with its proposed identity as an upstream caspase, caspase-2 could provoke the activation of caspase-7. Caspase-2 was not subject to inhibition by members of the IAP family of apoptosis inhibitors.
- Subjects
PROTEINS; BIOMOLECULES; APOPTOSIS; ENZYME inhibitors; CELL death; ORGANIC compounds
- Publication
FEBS Journal, 2005, Vol 272, Issue 6, p1401
- ISSN
1742-464X
- Publication type
Article
- DOI
10.1111/j.1742-4658.2005.04573.x