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- Title
Antipsychotics in the treatment of autism.
- Authors
Posey, David J.; Stigler, Kimberly A.; Erickson, Craig A.; McDougle, Christopher J.
- Abstract
Atypical antipsychotics have become indispensable in the treatment of a variety of symptoms in autism. They are frequently used to treat irritability and associated behaviors including aggression and self injury. They may also be efficacious for hyperactivity and stereotyped behavior. This review presents the rationale for the use of this drug class in autism and reviews the most important studies published on this topic to date. Significant adverse effects, including weight gain and the possibility of tardive dyskinesia, are reviewed. Future research directions are discussed.
- Subjects
ANTIPSYCHOTIC agents; TREATMENT of autism; HYPERKINESIA; STEREOTYPY (Psychiatry); AGGRESSION (Psychology); TARDIVE dyskinesia; AUTISM; COMPARATIVE studies; RESEARCH methodology; MEDICAL cooperation; RESEARCH; RESEARCH funding; SELF-mutilation; WEIGHT gain; EVALUATION research; DISEASE complications
- Publication
Journal of Clinical Investigation, 2008, Vol 118, Issue 1, p6
- ISSN
0021-9738
- Publication type
journal article
- DOI
10.1172/JCI32483