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- Title
Arylacetonitrilases: Potential Biocatalysts for Green Chemistry.
- Authors
Bhalla, Tek Chand; Thakur, Neerja; Kumar, Vijay
- Abstract
Nitrilases are the enzymes that catalyze the hydrolysis of nitriles to corresponding carboxylic acid and ammonia. They are broadly categorized into aromatic, aliphatic, and arylacetonitrilases based on their substrate specificity. Most of the studies pertaining to these enzymes in the literature have focused on aromatic and aliphatic nitrilases. However, arylacetonitrilases have attracted the attention of academia and industry in the last several years due to their aryl specificity and enantioselectivity. They have emerged as interesting biocatalytic tools in green chemistry to synthesize useful aryl acids such as mandelic acid and derivatives of phenylacetic acid. The aim of the present review is to collate information on the arylacetonitrilases and their catalytic properties including enantioselectivity and potential applications in organic synthesis.
- Subjects
PHENYLACETIC acid; ENZYMES; ACID derivatives; CARBOXYLIC acids; ORGANIC synthesis; NITRILES; SUSTAINABLE chemistry
- Publication
Applied Biochemistry & Biotechnology, 2024, Vol 196, Issue 4, p1769
- ISSN
0273-2289
- Publication type
Article
- DOI
10.1007/s12010-023-04643-2