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- Title
Concepts to Reveal Parvovirus–Nucleus Interactions.
- Authors
Mattola, Salla; Hakanen, Satu; Salminen, Sami; Aho, Vesa; Mäntylä, Elina; Ihalainen, Teemu O.; Kann, Michael; Vihinen-Ranta, Maija
- Abstract
Parvoviruses are small single-stranded (ss) DNA viruses, which replicate in the nucleoplasm and affect both the structure and function of the nucleus. The nuclear stage of the parvovirus life cycle starts at the nuclear entry of incoming capsids and culminates in the successful passage of progeny capsids out of the nucleus. In this review, we will present past, current, and future microscopy and biochemical techniques and demonstrate their potential in revealing the dynamics and molecular interactions in the intranuclear processes of parvovirus infection. In particular, a number of advanced techniques will be presented for the detection of infection-induced changes, such as DNA modification and damage, as well as protein–chromatin interactions.
- Subjects
PARVOVIRUS diseases; DNA viruses; MOLECULAR interactions; PARVOVIRUSES; MOLECULAR dynamics; CELL nuclei
- Publication
Viruses (1999-4915), 2021, Vol 13, Issue 7, p1306
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v13071306