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- Title
Highly Diastereo- and Enantioselective Silver-Catalyzed Double [3+2] Cyclization of α-Imino Esters with Isocyanoacetate.
- Authors
Shao, Pan ‐ Lin; Liao, Jia ‐ Yu; Ho, Yee Ann; Zhao, Yu
- Abstract
Presented herein is a new complexity-generating method in which both functionalities of α-imino esters undergo stereoselective cyclization with isocyanoacetates to produce directly linked oxazole-imidazolines, which can be transformed into highly functionalized α,β-diamino esters and imidazolinium salts in high diastereo- and enantiopurity.
- Subjects
DIASTEREOISOMERS; ENANTIOSELECTIVE catalysis; RING formation (Chemistry); IMINO compounds; STEREOSELECTIVE reactions; ENANTIOMERIC purity; ESTERS
- Publication
Angewandte Chemie, 2014, Vol 126, Issue 21, p5539
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201402788