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- Title
Invasive Geotrichum clavatum Fungal Infection in an Acute Myeloid Leukaemia Patient: A Case Report and Review.
- Authors
Camus, Vincent; Thibault, Marie-Laure; David, Marion; Gargala, Gilles; Compagnon, Patricia; Lamoureux, Fabien; Girault, Christophe; Michot, Jean-Baptiste; Stamatoullas, Aspasia; Lanic, Hélène; Jardin, Fabrice; Lenain, Pascal; Tilly, Hervé; Leprêtre, Stéphane
- Abstract
Invasive Geotrichum clavatum fungal infections are extremely rare and unusual, occurring nearly exclusively in patients experiencing prolonged neutropenia during the treatment for acute myeloid leukaemia. Several groups of cases of fatal G. clavatum infection were reported in France between 2011 and 2012, but the ecological niche has not yet been identified. We report a case of a 32-year-old patient with acute myeloid leukaemia who developed G. clavatum sepsis with primary peritonitis, hepatic nodular lesions, and multivisceral failure during aplasia after induction followed by salvage chemotherapy. He was treated with voriconazole and is still alive 1 year after with controlled disease. We then discuss the epidemiological, clinical, and therapeutic features of these serious fungal infections compared to the published data.
- Subjects
ACUTE myeloid leukemia; ACUTE myeloid leukemia treatment; MYCOSES; GEOTRICHUM; NEUTROPENIA; PATIENTS
- Publication
Mycopathologia, 2014, Vol 177, Issue 5/6, p319
- ISSN
0301-486X
- Publication type
Article
- DOI
10.1007/s11046-014-9746-4