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- Title
The utility of Hibiscus sabdariffa L. to prepare metal oxides NPs for clinical application on osteoporosis supported by theoretical study.
- Authors
Al-Garawi, Zahraa S.; Al-Qaisi, Ahmad H. Ismail; Al-Shamari, Kawthar Amer; Öztürkkan, Füreya Elif; Necefoğlu, Hacali
- Abstract
Green synthesis of metal oxides as a treatment for bone diseases is still exploring. Herein, MgO and Fe2O3 NPs were prepared from the extract of Hibiscus sabdariffa L. to study their effect on vit D3, Ca+2, and alkaline phosphatase enzyme ALP associated with osteoporosis. Computational chemistry was utilized to gain insight into the possible interactions. These oxides were characterized by X-ray diffraction, SEM, FTIR, and AFM. Results revealed that green synthesis of MgO and Fe2O3 NPs was successful with abundant. MgO NPs were in vitro applied on osteoporosis patients (n = 35) and showed a significant elevation of vit D3 and Ca+2 (0.0001 > p < 0.001) levels, compared to healthy volunteers (n = 25). Thus, Hibiscus sabdariffa L. is a good candidate to prepare MgO NPs, with a promising enhancing effect on vit D3 and Ca+2 in osteoporosis. In addition, interactions of Fe2O3 and MgO NPs with ALP were determined by molecular docking study.
- Subjects
ROSELLE; METALLIC oxides; OSTEOPOROSIS; CLINICAL medicine; COMPUTATIONAL chemistry; BONE diseases; TERIPARATIDE
- Publication
Bioprocess & Biosystems Engineering, 2024, Vol 47, Issue 5, p753
- ISSN
1615-7591
- Publication type
Article
- DOI
10.1007/s00449-024-03012-5