We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Defining brain wiring patterns and mechanisms through gene trapping in mice.
- Authors
Leighton, Philip A.; Mitchell, Kevin J.; Goodrich, Lisa V.; Xiaowei Lu; Pinson, Kathy; Scherz, Paul; Skarnes, William C.; Tessier-Lavigne, Marc
- Abstract
Describes a phenotype-based gene-trap screen in mice designed for the large-scale identification of genes controlling the formation of connections in the mammalian brain. Use of an axonal marker, which helps identify cell-autonomous mechanisms in axon guidance; Mention of patterns of axonal labelling, which facilitate analysis of a normal wiring diagram of the brain; Details of an in vivo guidance function for a vertebrate transmembrane semaphorin, Sema6A; Re-evaluation of the Eph receptor EphA4.
- Subjects
AXONAL transport; NEURAL circuitry; BRAIN research; LABORATORY mice
- Publication
Nature, 2001, Vol 410, Issue 6825, p174
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/35065539