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- Title
Expression of the transcription factor delta-FosB in the brain controls sensitivity to cocaine.
- Authors
Kelz, Max B.; Chen, Jingshan; Carlezon Jr., William A.; Whisler, Kim; Gilden, Lauren; Beckmann, Alison M.; Steffen, Cathy; Zhang, Ya-Jun; Marotti, Louis; Self, David W.; Tkatch, Tatiana; Baranauskas, Gytis; Surmeier, D. James; Neve, Rachael L.; Duman, Ronald S.; Picciotto, Marina R.; Nestler, Eric J.
- Abstract
Presents a study using transgenic mice in which DeltaFosB can be induced in adults in the subset of nucleus accumbens neurons in which cocaine induces the protein, to show that DeltaFosB expression increases the responsiveness of an animal to the rewarding and locomotor-activating effects of cocaine. Support for a model in which DeltaFosB, by altering gene expression, enhances sensitivity to cocaine and may thereby contribute to cocaine addiction.
- Subjects
COCAINE abuse; COCAINE; TRANSGENIC mice; GENE expression; SCIENTIFIC experimentation; PHYSIOLOGY
- Publication
Nature, 1999, Vol 401, Issue 6750, p272
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/45790