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- Title
Association between serum amyloid A and obesity: a meta-analysis and systematic review.
- Authors
Zhao, Yulan; He, Xuelian; Shi, Xuegui; Huang, Chengjin; Liu, Jie; Zhou, Shuli; Heng, Chew-Kiat
- Abstract
Emerging evidence indicates an association of the acute-phase protein serum amyloid A (SAA) with obesity. Here we review and summarize quantitatively the available data related to this association. PubMed was systematically searched using the terms “serum amyloid A” and “obesity.” Eighty-one relevant studies between January 1966 and July 2009 were identified. Of these, only 11 cross-sectional studies and 10 prospective studies with successful interventions met our inclusion criteria for the meta-analysis. All analyses were conducted using the Comprehensive Meta-Analysis software. Literature pertaining to the relationship between SAA and other inflammatory markers, and the association between SAA and obesity-related disorders, such as cardiovascular diseases, atherosclerosis, diabetes, and insulin resistance was also reviewed. A strong association between body mass index and SAA levels was found in the 11 cross-sectional studies. The overall correlation coefficient is 0.230 (95% CI 0.160–0.297, P < 0.0005). The ten prospective studies were subsequently analyzed, and the difference in SAA levels before and after weight loss, expressed as standardized mean difference was −0.480 (95% CI −0.678 to −0.283, P < 0.0005). We discuss some potential underlying mechanisms and clinical applications for reducing SAA levels in obesity.
- Subjects
AMYLOID; SERUM; OBESITY; CARDIOVASCULAR diseases; ATHEROSCLEROSIS
- Publication
Inflammation Research, 2010, Vol 59, Issue 5, p323
- ISSN
1023-3830
- Publication type
Article
- DOI
10.1007/s00011-010-0163-y