We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
IL-23 and IL-17 in the establishment of protective pulmonary CD4<sup>+</sup> T cell responses after vaccination and during Mycobacterium tuberculosis challenge.
- Authors
Khader, Shabaana A; Bell, Guy K; Pearl, John E; Fountain, Jeffrey J; Rangel-Moreno, Javier; Cilley, Garth E; Shen, Fang; Eaton, Sheri M; Gaffen, Sarah L; Swain, Susan L; Locksley, Richard M; Haynes, Laura; Randall, Troy D; Cooper, Andrea M
- Abstract
Interferon-γ is key in limiting Mycobacterium tuberculosis infection. Here we show that vaccination triggered an accelerated interferon-γ response by CD4+ T cells in the lung during subsequent M. tuberculosis infection. Interleukin 23 (IL-23) was essential for the accelerated response, for early cessation of bacterial growth and for establishment of an IL-17-producing CD4+ T cell population in the lung. The recall response of the IL-17-producing CD4+ T cell population occurred concurrently with expression of the chemokines CXCL9, CXCL10 and CXCL11. Depletion of IL-17 during challenge reduced the chemokine expression and accumulation of CD4+ T cells producing interferon-γ in the lung. We propose that vaccination induces IL-17-producing CD4+ T cells that populate the lung and, after challenge, trigger the production of chemokines that recruit CD4+ T cells producing interferon-γ, which ultimately restrict bacterial growth.
- Publication
Nature Immunology, 2007, Vol 8, Issue 4, p369
- ISSN
1529-2908
- Publication type
Article
- DOI
10.1038/ni1449