We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Inactivation of Notch1 in immature thymocytes does not perturb CD4 or CD8 T cell development.
- Authors
Wolfer, Anita; Bakker, Talitha; Wilson, Anne; Nicolas, Michael; Ioannidis, Vassilios; Littman, Dan R.; Wilson, Christopher B.; Held, Werner; MacDonald, H. Robson; Radtke, Freddy
- Abstract
Notch proteins influence cell-fate decisions in many developing systems. Several gain-of-function studies have suggested a critical role for Notch1 signaling in CD4-CD8 lineage commitment, matura-tion and survival in the thymus. However, we show here that tissue-specific inactivation of the gene encoding Notch1 in immature (CD25+CD44-) T cell precursors does not affect subsequent thymocyte development. Neither steady-state numbers nor the rate of production of CD4+ and CD8+ mature thymocytes is perturbed in the absence of Notch1. In addition, Notch1-deficient thymocytes are normally sensitive to spontaneous or glucocorticoid-induced apoptosis. In contrast to earlier re-ports, these data formally exclude an essential role for Notch1 in CD4-CD8 lineage commitment, maturation or survival.
- Subjects
NOTCH genes; T cells
- Publication
Nature Immunology, 2001, Vol 2, Issue 3, p235
- ISSN
1529-2908
- Publication type
Article
- DOI
10.1038/85294