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- Title
IDENTIFICATION OF PROTEINS OF LAMINATED LAYER OF ECHINOCOCCUS GRANULOSUS: INTERFACE AMONG HOST AND PARASITE.
- Authors
Zeghir-Bouteldja, Razika; Touil-Boukoffa, Chafia
- Abstract
Our study is focused on the identification of proteins associated to the laminated layer which constitutes the interface between metacestode and the host immune response. In this context, protein extracts were separated by SDS-PAGE and analyzed by nano-liquid chromatography-coupled tandem mass spectrometry. Our results revealed the presence of both host and parasite proteins. Most of the host proteins were sera proteins and would be involved in the immune response, indicating their involvement in the local inflammatory response and others involved in transport. Interestingly, our results also identified a few parasitic proteins such as glioma pathogenesis protein 1, paramyosin, and myoferlin. Globally, our study indicated the presence of proteins that might be involved in host-parasite interaction and pointed some of them as potential drug and vaccine targets.
- Subjects
ECHINOCOCCUS granulosus; PROTEOMICS; TANDEM mass spectrometry; BLOOD proteins
- Publication
Veterinaria, 2022, Vol 71, Issue 1, p53
- ISSN
0372-6827
- Publication type
Article
- DOI
10.51607/22331360.2022.71.1.53