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- Title
Disruption of prepulse inhibition by 3,4-methylenedioxymethamphetamine (MDMA): comparison between male and female wild-type and 5-HT1A receptor knockout mice.
- Authors
van den Buuse, Maarten; Becker, Thorsten; Kwek, Perrin; Martin, Sally; Ruimschotel, Emma; Risbrough, Victoria
- Abstract
The aim of this study was to investigate the involvement of serotonin-1A (5-HT1A) receptors in the effects of 3,4-methylenedioxymetamphetamine (MDMA) on prepulse inhibition of acoustic startle (PPI) by comparing male and female wild-type (WT) mice and 5-HT1A receptor knockout (1AKO) mice. MDMA dose-dependently decreased PPI in male and female mice although female mice were more sensitive at the 100-ms inter-stimulus interval (ISI). In male mice, 10 mg/kg MDMA disrupted PPI in 1AKO but not in WT controls. There was no genotype difference at higher or lower doses of MDMA. In female mice, there was no difference between genotypes at any dose of MDMA. Average startle was reduced by 10 mg/kg and 20 mg/kg MDMA similarly in male and female mice and all genotypes. These results show an involvement of 5-HT1A receptors in the effect of MDMA on PPI in male, but not female mice.
- Subjects
ECSTASY (Drug); DRUG side effects; SEROTONIN; SCHIZOPHRENIA; ANIMAL models in research; COMPARATIVE studies; STARTLE reaction; LABORATORY mice
- Publication
International Journal of Neuropsychopharmacology, 2011, Vol 14, Issue 6, p856
- ISSN
1461-1457
- Publication type
Article
- DOI
10.1017/S1461145711000101