We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A Systematic Review and Meta-Analysis Comparing Heterogeneity in Body Mass Responses Between Low-Carbohydrate and Low-Fat Diets.
- Authors
Smith, Eleanor S.; Smith, Harry A.; Betts, James A.; Gonzalez, Javier T.; Atkinson, Greg
- Abstract
<bold>Objective: </bold>An important notion in personalized medicine is that there is clinically relevant treatment response heterogeneity. Low-carbohydrate (CHO) and low-fat diets are widely adopted to reduce body mass. To compare individual differences in responses between two dietary interventions, a formal statistical comparison of response variances between study arms in a randomized controlled trial (RCT) is crucial.<bold>Methods: </bold>The change in variances in RCTs for the body mass responses to low-CHO dietary interventions versus change variances for the low-fat groups (typically considered as the comparator intervention) were compared. A literature search identified relevant RCTs (n = 25; 3,340 participants). The means and SDs of body mass change in low-CHO and low-fat study arms were extracted to calculate the variances of individual responses. These were meta-analyzed in a random-effects model and converted to the SD for individual responses.<bold>Results: </bold>The pooled SD for individual responses for body mass was 1.4 kg (95% CI: -1.1 to 2.3) with a wide 95% prediction interval of -6.3 to 10.4 kg.<bold>Conclusions: </bold>Evidence is insufficient to suggest the response heterogeneity to low-CHO diets differs from that observed with low-fat diets.
- Subjects
LOW-fat diet; LOW-carbohydrate diet; META-analysis; FORECASTING; RANDOMIZED controlled trials; BODY weight; SYSTEMATIC reviews; BODY mass index
- Publication
Obesity (19307381), 2020, Vol 28, Issue 10, p1833
- ISSN
1930-7381
- Publication type
journal article
- DOI
10.1002/oby.22968