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- Title
Clinical outcomes after Descemet’s stripping endothelial keratoplasty using donor corneas from children younger than 3 years.
- Authors
Peng, Rong‐mei; Guo, Yu‐xin; Qiu, Yuan; Hong, Jing; Xiao, Ge‐ge; Qu, Hong‐qiang
- Abstract
Abstract: Importance: There is limited literature on paediatric donors in endothelial keratoplasty. Background: This study investigated the efficacy of and appropriate paediatric donor age for Descemet’s stripping endothelial keratoplasty (DSEK). Design: Retrospective and observational case series. Participants: Thirty‐eight consecutive patients underwent DSEK with paediatric donor corneas. Methods: The age of the donors ranged from 32 weeks gestation (premature neonate) to 3 years old. All donor consents were obtained from the parents. The causes of donor death included traffic accident, congenital heart disease and neonatal respiratory distress syndrome. Main Outcome Measures: The outcome measures included best‐corrected visual acuity, endothelial cell loss and complications. Results: Best‐corrected visual acuity at last follow‐up was >20/40 in 28 of 38 eyes (73.7%). The mean preoperative endothelial cell density of donor corneas was 4682 ± 520 cells/mm2. The mean endothelial cell density of grafts was 3977 ± 556 cells/mm2 at 18 months postoperatively. Three lenticules from premature neonate donors exhibited severe contraction postoperatively. The edge of six lenticules from donors <1‐year‐old exhibited contraction in the early postoperative period and gradually flattened spontaneously. Graft detachment occurred in one patient. Conclusions and Relevance: DSEK with paediatric donor corneas can achieve good clinical outcomes. The corneal lenticules from 1‐ to 3‐year‐ old donors are suitable for DSEK while those from donors <1‐year‐old are less suitable due to the possibility of severe postoperative graft contraction.
- Subjects
CORNEA surgery; CHILDREN; PEDIATRICS; PREGNANCY; ORGAN donors; CONGENITAL heart disease; RESPIRATORY distress syndrome; ENDOTHELIAL cells; DESCEMET stripping endothelial keratoplasty
- Publication
Clinical & Experimental Ophthalmology, 2018, Vol 46, Issue 7, p721
- ISSN
1442-6404
- Publication type
Article
- DOI
10.1111/ceo.13186