We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Submonolayer biolasers for ultrasensitive biomarker detection.
- Authors
Gong, Chaoyang; Yang, Xi; Tang, Shui-Jing; Zhang, Qian-Qian; Wang, Yanqiong; Liu, Yi-Ling; Chen, Yu-Cheng; Peng, Gang-Ding; Fan, Xudong; Xiao, Yun-Feng; Rao, Yun-Jiang; Gong, Yuan
- Abstract
Biomarker detection is key to identifying health risks. However, designing sensitive and single-use biosensors for early diagnosis remains a major challenge. Here, we report submonolayer lasers on optical fibers as ultrasensitive and disposable biosensors. Telecom optical fibers serve as distributed optical microcavities with high Q-factor, great repeatability, and ultralow cost, which enables whispering-gallery laser emission to detect biomarkers. It is found that the sensing performance strongly depends on the number of gain molecules. The submonolayer lasers obtained a six-order-of-magnitude improvement in the lower limit of detection (LOD) when compared to saturated monolayer lasers. We further achieve an ultrasensitive immunoassay for a Parkinson's disease biomarker, alpha-synuclein (α-syn), with a lower LOD of 0.32 pM in serum, which is three orders of magnitude lower than the α-syn concentration in the serum of Parkinson's disease patients. Our demonstration of submonolayer biolaser offers great potentials in high-throughput clinical diagnosis with ultimate sensitivity.
- Publication
Light: Science & Applications, 2023, Vol 12, Issue 1, p1
- ISSN
2047-7538
- Publication type
Article
- DOI
10.1038/s41377-023-01335-8