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- Title
Dynamic changes of acquired maternal SARS-CoV-2 IgG in infants.
- Authors
Wang, Xia; Yang, Pu; Zheng, Junwen; Liu, Pin; Wei, Cong; Guo, Juanjuan; Zhang, Yuanzhen; Zhao, Dongchi
- Abstract
At present, there are still ambiguous reports about the perinatal infection of infants born to mothers infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The dynamic characteristics of infantile serum antibodies born to mother with SARS-CoV-2 has not been well described. In this study, we analyzed the seroconversion of 27 newborns born to 26 pregnant women infected with SARS-CoV-2. The SARS-CoV-2 IgG positive rate of parturient was 80.8%, and half of their infants obtained maternal IgG. IgG transfer rates were 18.8% and 81.8% in those infants whose mother infected less and more than 2 weeks before delivery. In the first two months of life, the IgG level of infants dropped sharply to one tenth of that at birth. These results suggest that maternal SARS-CoV-2 IgG provides limited protection for infants.
- Subjects
IMMUNOGLOBULIN G; SARS-CoV-2; INFANTS; PREGNANT women; SERUM
- Publication
Scientific Reports, 2021, Vol 11, Issue 1, p1
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/s41598-021-87535-x