We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Coiled-coil domain containing 50-V2 protein positively regulates neurite outgrowth.
- Authors
Min, Ju-Sik; Halder, Debasish; Yoon, Ji-Yong; Jeon, Su-Jin; Jun, Soo Young; Lee, Jae-Ran; Lee, Jeong-Ju; Choi, Min-Hyuk; Jung, Cho-Rok; Lee, DaYong; Kim, Byoung-Joon; Kim, Nam-Soon
- Abstract
The coiled-coil domain containing 50 (CCDC50) protein is a phosphotyrosine-dependent signalling protein stimulated by epidermal growth factor. It is highly expressed in neuronal cells in the central nervous system; however, the roles of CCDC50 in neuronal development are largely unknown. In this study, we showed that the depletion of CCDC50-V2 impeded the neuronal development process, including arbor formation, spine density development, and axonal outgrowth, in primary neurons. Mechanistic studies revealed that CCDC50-V2 positively regulated the nerve growth factor receptor, while it downregulated the epidermal growth factor receptor pathway. Importantly, JNK/c-Jun activation was found to be induced by the CCDC50-V2 overexpression, in which the interaction between CCDC50-V2 and JNK2 was also observed. Overall, the present study demonstrates a novel mechanism of CCDC50 function in neuronal development and provides new insight into the link between CCDC50 function and the aetiology of neurological disorders.
- Subjects
PHOSPHOTYROSINE; EPIDERMAL growth factor; CENTRAL nervous system; ETIOLOGY of diseases; NEUROLOGICAL disorders
- Publication
Scientific Reports, 2020, Vol 10, Issue 1, p1
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/s41598-020-78304-3