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- Title
Complete atrioventricular block associated with dapsone therapy: a rare complication of dapsone-induced hypersensitivity syndrome.
- Authors
Zhu, K. J.; He, F. T.; Jin, N.; Lou, J. X.; Cheng, H.
- Abstract
Dapsone is still widely used for a range of infectious and inflammatory diseases. A potential severe side-effect, known as dapsone-induced hypersensitivity syndrome (DHS), may occur. DHS is characterized by fever, skin rashes, lymphadenopathy and multiorgan dysfunction manifesting as hepatitis, cholangitis, pneumonitis, colitis, thyroiditis and myocarditis. However, DHS-associated complete atrioventricular block has not previously been reported. We describe here a 45-year-old Chinese woman who developed DHS after 5 weeks of dapsone therapy for pustular palmoplantar psoriasis. In addition to typical DHS symptoms, she experienced several episodes of syncope as a result of complete atrioventricular block which was successfully reversed with a permanent pacemaker implantation.
- Subjects
DAPSONE; ATRIOVENTRICULAR node; ALLERGIES; HEPATITIS; PSORIASIS
- Publication
Journal of Clinical Pharmacy & Therapeutics, 2009, Vol 34, Issue 4, p489
- ISSN
0269-4727
- Publication type
Article
- DOI
10.1111/j.1365-2710.2008.00991.x