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- Title
Molecular analysis of thiopurine S-methyltransferase alleles in Taiwan aborigines and Taiwanese.
- Authors
Lu, H.-F.; Shih, M.-C.; Chang, Y.-S.; Chang, J.-Y.; Ko, Y.-C.; Chang, S.-J.; Chang, J.-G.
- Abstract
Background: Thiopurine S-methyltransferase (TPMT) is a cytosolic enzyme involved in the metabolism of these thiopurine drugs. Methylation of thiopurine drugs by TPMT competes with the formation of their active 6-thioguanine nucleotide metabolite, thereby potentially modulating the therapeutic and toxic effects of these drugs. Objective: To analyze the thiopurine S-methyltransferase allelic frequencies in Taiwan aborigines and Taiwanese. Methods: We used polymerase chain reaction–restriction fragment length polymorphism method to determine the allelic frequencies of TPMT variants (TPMT*1–TPMT*8) in 409 Taiwan aborigines and 117 Taiwanese. Results and discussion: The results showed that the allelic frequencies of TPMT*1 were 99·88% and 98·72% for Taiwan aborigines and Taiwanese respectively. The allelic frequencies of TPMT*3C were 0·12% and 1·28% for Taiwan aborigines and Taiwanese respectively. No TPMT*2, 3A, 3B, 3D and 4–8 were found in these populations. Conclusion: Our results provide useful information for using thiopurine drugs in these populations.
- Subjects
METHYLATION; POLYMERASE chain reaction; MOLECULES; GENETIC polymorphisms; ALLELES; TAIWANESE people
- Publication
Journal of Clinical Pharmacy & Therapeutics, 2006, Vol 31, Issue 1, p93
- ISSN
0269-4727
- Publication type
Article
- DOI
10.1111/j.1365-2710.2006.00707.x