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- Title
Polycystins: inhibiting the inhibitors.
- Authors
Benezra, Robert
- Abstract
Polycystin-1 and -2 — two integral membrane proteins that are mutated in polycystic kidney disease — regulate the cell cycle by preventing nuclear localization of the pro-proliferative helix-loop-helix (HLH) protein Id2. This novel mechanism for restraining Id proteins has important implications for our understanding of the nature of polycystic kidney disease and perhaps other proliferative disorders.
- Subjects
RADIOLARIA; ENZYME inhibitors; POLYCYSTIC kidney disease; CYSTIC kidney disease; MEMBRANE proteins; HUMAN chromosome abnormalities; GENETIC mutation
- Publication
Nature Cell Biology, 2005, Vol 7, Issue 12, p1064
- ISSN
1465-7392
- Publication type
Article
- DOI
10.1038/ncb1205-1064