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- Title
Dual role of the fringe connection gene in both heparan sulphate and fringe-dependent signalling events.
- Authors
Selva, Erica M.; Hong, Kyoungja; Baeg, Gyeong-Hun; Beverley, Stephen M.; Turco, Salvatore J.; Perrimon, Norbert; Häcker, Udo
- Abstract
The precise regulation of growth factor signalling is crucial to the molecular control of development in Drosophila. Post-translational modification of signalling molecules is one of the mechanisms that modulate developmental signalling specificity. We describe a new gene, fringe connection (frc), that encodes a nucleotide?sugar transporter that transfers UDP?glucuronic acid, UDP?N-acetylglucosamine and possibly UDP?xylose from the cytoplasm into the lumen of the endoplasmic reticulum/Golgi. Embryos with the frc mutation display defects in Wingless, Hedgehog and fibroblast growth factor signalling. Clonal analysis shows that fringe-dependent Notch signalling is disrupted in frc mutant tissue.
- Subjects
PROTEINS; GENES; CELLULAR signal transduction; PROTEOGLYCANS; DROSOPHILA
- Publication
Nature Cell Biology, 2001, Vol 3, Issue 9, p809
- ISSN
1465-7392
- Publication type
Article
- DOI
10.1038/ncb0901-809