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- Title
Local caspase activity directs engulfment of dendrites during pruning.
- Authors
Williams, Darren W.; Kondo, Shu; Krzyzanowska, Agnieszka; Hiromi, Yasushi; Truman, James W.
- Abstract
Pruning is important for sculpting neural circuits, as it removes excessive or inaccurate projections. Here we show that the removal of sensory neuron dendrites during pruning in Drosophila melanogaster is directed by local caspase activity. Suppressing caspase activity prevented dendrite removal, whereas a global activation of caspases within a neuron caused cell death. A new genetically encoded caspase probe revealed that caspase activity is confined to the degenerating dendrites of pruning neurons.
- Subjects
NEURAL circuitry; DENDRITES; SENSORY neurons; SYNAPSES; CELL death; DROSOPHILA melanogaster
- Publication
Nature Neuroscience, 2006, Vol 9, Issue 10, p1234
- ISSN
1097-6256
- Publication type
Article
- DOI
10.1038/nn1774