We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Lacidipine: effects on vascular pressor responses throughout the dosage interval in normotensive subjects.
- Authors
Ueda, Shinichiro; Donnelly, Richard; Panfilov, Vsevolod; Morris, Andrew D.; Elliott, Henry L.
- Abstract
Aims To assess the duration and consistency of the pharmacological activity of the dihydropyridine calcium antagonist drug, lacidipine. Methods Eight healthy normotensive young males participated in a double-blind randomised crossover comparison of single and multiple doses (for 2 weeks) of lacidipine and placebo. The calcium antagonist effects were quantified at 2, 6 and 24 h post dose by the extent of the attenuation of the pressor responses to the intravenous administration of the vasoconstrictors angiotensin II and noradrenaline. Results After 2 weeks of treatment, lacidipine consistently and significantly attenuated the pressor responses to both agents at 2 h post dose. At 6 and 24 h post dose there was a significant and progressive decline in the effectiveness of lacidipine in attenuating the pressor responses and for the response to angiotensin II there was no statistically significant effect at either 6 or 24 h post dose. Conclusions These results indicate that there is an obvious ‘peak’ in the pharmacological activity of lacidipine at about 2 h post dose and that this activity is not fully and consistently maintained throughout 24 h.
- Subjects
LACIDIPINE; VASCULAR resistance
- Publication
British Journal of Clinical Pharmacology, 1998, Vol 46, Issue 2, p127
- ISSN
0306-5251
- Publication type
Article
- DOI
10.1046/j.1365-2125.1998.00760.x