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- Title
Transfusion-related Acute Lung Injury.
- Authors
Miok Kim
- Abstract
Transfusion-related acute lung injury (TRALI) is a significant cause of iatrogenic injuries in patients. It is also the major cause of transfusion-associated fatalities. Pathophysiologic mechanism is an implicated donor of HLA. Neutrophil antibodies and biologic response modifiers are accumulated in the stored blood products. Pulmonary endothelial activation of the host may be the response from these mediators. Treatment is supportive and will be subjected to other forms of ALL/ARDS. Diverting donors at high risk for alloimmunization may decrease the incidence of such cases.
- Subjects
LUNG injuries; IATROGENIC diseases; BLOOD transfusion; HLA histocompatibility antigens; ADULT respiratory distress syndrome; BLOOD donors; DISEASE risk factors; INJURY risk factors
- Publication
Korean Journal of Critical Care Medicine, 2012, Vol 27, Issue 1, p1
- ISSN
1229-4802
- Publication type
Article
- DOI
10.4266/kjccm.2012.27.1.1