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- Title
Regulation of Adhesion Molecules: A New Target for the Treatment of Chronic Venous Insufficiency.
- Authors
Verbeuren, Tony J.; Bouskela, Eliete; Cohen, Richard A.; Vanhoutte, Paul M.
- Abstract
As more insight into file mechanisms leading to chronic venous insufficiency (CVI) is gained, novel targets for drug treatment of the disease, m, of its complications, become available. Studies using chemical entities capable of inhibiting leukocyte adhesion in postcapillary venules have led to the discovery of selective inhibitors of cell adhesion mechanisms. The aim of the current review is to describe the pharmacology, biochemistry, and molecular biology studies performed with some new inhibitors of adhesion molecule expression. Compounds such as hydroxy triallyl farnisine (S 17834) may offer new and efficient treatment of the microcirculatory complications that accompany chronic venous disease.
- Subjects
CELL adhesion molecules; VENOUS insufficiency; VEIN diseases; MICROCIRCULATION disorders; BLOOD circulation disorders; MICROCIRCULATION; LEUCOCYTE adherence inhibition test; MOLECULAR biology; THERAPEUTICS
- Publication
Microcirculation, 2000, Vol 7, pS41
- ISSN
1073-9688
- Publication type
Article
- DOI
10.1080/mic.7.S1.S41.S48