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- Title
Glutathione S-transferase π Levels in a Panel of Lung Cancer Cell Lines and Its Relation to Chemo-radiosensitivity.
- Authors
Hida, Toyoaki; Ariyoshi, Yutaka; Kuwabara, Masaki; Sugiura, Takahiko; Takahashi, Takashi; Takahashi, Toshitada; Hosoda, Kenji; Niitsu, Yoshiro; Ueda, Ryuzo
- Abstract
The human placental form of glutathione S-transferase π (GST-π) was measured by a sandwich enzyme-linked immunosorbent assay in lung cancer cell lines established in our laboratories. In classic-type small cell lung cancer (SCLC, variant-type SCLC and non-small cell lung cancer (NSCLQ, the respective mean GST-π values were 0.83 ±0.88, 3.27±2.85 and 2.40±0.76 μg/mg protein. Cell lines with high GST-π content had low levels of neuron specific enolase, which is known as a representative tumor marker for SCLC. This suggests that GST-π may also be used as a potential marker for NSCLC. The lines with low GST-π content were more sensitive to radiation than those with high GST-π content. Cell lines not subjected to prior therapy also showed a good correlation between GST-π levels and chemosensitivity to cisplatin. The findings suggest that GST-π can be used as an adjunctive marker for lung cancer.
- Publication
Japanese Journal of Clinical Oncology, 1993, Vol 23, Issue 1, p14
- ISSN
0368-2811
- Publication type
Article