We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Expressive levels of imuunomarkers and their clinicopathologic significance in the benign and malignant lesions of gallbladder.
- Authors
Agarwal, Anshoo; Bansal, Rani; Chauhan, Kavita; Gupta, Mamta
- Abstract
Background: Worldwide gall bladder cancer (GBC) is known to be the commonest malignant tumour of the biliary tract. It is the most aggressive carcinoma of the biliary tract with short median survival from the time of diagnosis. The aggressive biologic behavior of the carcinoma and non-availability of sensitive screening tests for early detection may be responsible for the poor prognosis associated with GBC. Owing to the delayed diagnosis at an advanced stage, only few of the patients are found to be eligible for a curative surgical resection. Material and Methods: All patients diagnosed with neoplastic and non-neoplastic gallbladder lesions in the Department of Pathology, Subharti Medical College were included in the study between the year 2017-2019. The Hematoxylin and Eosin stained biopsies of 320 patients were assessed and out of them 100 patients were chosen as the sample for the study. The clinicopatholgical data of the 100 patients were compiled into a data base and de-identified. Results: In adenocarcinoma - biliary type, there was positive EGFR expression seen in 64.71% of cases compared to negative expression seen in 35.29% cases, the difference was not statistically significant (p = 0.18). Adenocarcinoma - papillary ype showed positive expression. Adenocarcinoma--intestinal type showed negative EGFR expression, but again, without statistical significance (p = 0.24). Conclusions: The minimal response of advanced cases of GBC to traditional treatments calls for new prognostic and treatment perspectives to be identified. Novel prognostic biomarkers could bring about the needed breakthrough in this regard as they will help in the identification of patients who will benefit tremendously from adjuvant and targeted therapies.
- Subjects
GALLBLADDER cancer; GALLBLADDER; BILIARY tract; PROGNOSIS; DELAYED diagnosis; CLINICAL pathology
- Publication
Journal of Cardiovascular Disease Research (Journal of Cardiovascular Disease Research), 2024, Vol 15, Issue 6, p1
- ISSN
0975-3583
- Publication type
Article