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- Title
CORRELATION OF SERUM ZINC-ALPHA-2- GLYCOPROTEIN WITH THYROID HORMONE IN NEWLY DIAGNOSED HYPERTHYROIDISM.
- Authors
Ali, Ahmed Nofal; Salem, Ihab Mohamed; Hussein, Atef Gouda; Hamed, Mohamed Gaber
- Abstract
Background: Patients with long-standing untreated hyperthyroidism may develop atrial fibrillation or heart failure. Treatment of hyperthyroidism requires accurate identification of underlying etiology. ZAG is known to be a lipid-mobilizing adipokine .It is involved in lipid metabolism in several ways. The purpose of the study to correlate of ZAG with thyroid hormones (FT3 & FT4) and to illustrate role of ZAG as a predictor for the outcome of treatment in patients newly diagnosed hyperthyroidism. Patients and methods: The study included 46 patients divided as 23 in the case group and 23 in the control group. Carbimazole was given to case group for three months and re-evaluated. All participants in this study were subjected to full history and thorough clinical examination. Laboratory investigation including: liver function tests, thyroid function tests, lipogram and fasting plasma glucose were done. Radiological thyroid scan was investigated. All tested parameters were performed before and after treartment. Results: There was negative correlation between ZAG and fasting plasma glucose in hyperthyroidism case group.ZAG was significantly higher in case group than control group and return to normal values after obtaining normal thyroid function.Thyroid hormone upregulates ZAG production in a dose-dependent manner. This up-regulation of ZAG induced by thyroid hormone in the liver leading to a significant increase in ZAG circulating levels. The decreased ZAG levels were significantly correlated with the decreased FT3 even after adjustment for the independent variables of age, gender and BMI. Conclusion: ZAG levels were positively related with serum free T3 levels after adjusting for age, gender and BMI in patients with newly diagnosed hyperthyroidism both before and after treatment with carbimazole. ZAG will return to normal values after obtaining normal thyroid function.
- Subjects
GLYCOPROTEIN hormones; THYROID hormones; THYROID diseases; HYPERTHYROIDISM; THYROID gland function tests; ATRIAL fibrillation
- Publication
Journal of Cardiovascular Disease Research (Journal of Cardiovascular Disease Research), 2021, Vol 12, Issue 3, p2371
- ISSN
0975-3583
- Publication type
Article