We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Ingestion of Bean Leaves Reduces Metabolic Complications and Restores Intestinal Integrity in C57BL/6 Mice with Obesity Induced by a High-Fat and High-Fructose Diet.
- Authors
Ocampo-Anguiano, Perla Viridiana; Victoria-Ruiz, Laura Lizeth; Reynoso-Camacho, Rosalía; Olvera-Ramírez, Andrea Margarita; Rocha-Guzmán, Nuria Elizabeth; Ramos-Gómez, Minerva; Ahumada-Solórzano, Santiaga Marisela
- Abstract
Consumption of foods with fiber and compounds can promote gastrointestinal health and reduce obesity complications. Therefore, treatment with common bean leaves (BL) against obesity was evaluated in mice with a high-fat and high-fructose diet (HFFD) for 14 weeks. The bromatological and phytochemical characterization of BL were determined. Afterwards, the animals were supplemented with BL (10%) or a standard diet (SD) as a strategy to encourage a healthy diet for 12 additional weeks. Changes in body composition, lipid profile, and intestinal integrity were analyzed. The characterization of BL stood out for its content of 27.2% dietary fiber, total phenolics (475.04 mg/100 g), and saponins (2.2 mg/100 g). The visceral adipose tissue (VAT) decreased in the BL group by 52% compared to the HFFD group. Additionally, triglyceride levels were 23% lower in the BL consumption group compared to the HFFD group. The improvement in lipid profile was attributed to the 1.77-fold higher fecal lipid excretion in the BL consumption group compared to the HFFD group and the inhibition of pancreatic lipase by 29%. Furthermore, BL supplementation reduced the serum levels of IL-6 (4.4-fold) and FITC–dextran by 50% compared with those in the HFFD group. Metabolic endotoxemia was inhibited after BL supplementation (−33%) compared to the HFFD group. BL consumption as a treatment in obese mice reduces adipose tissue accumulation and improves the lipid profile. Furthermore, we report for the first time that BL consumption improves intestinal integrity.
- Subjects
OBESITY complications; ANALYSIS of triglycerides; LIPID analysis; REDUCING diets; BODY composition; DIETARY fiber; PHENOLS; ANIMAL experimentation; DIET; FRUCTOSE; DIETARY supplements; PHYTOCHEMICALS; LEAVES; METABOLIC syndrome; RESEARCH funding; NATURAL foods; MICE; DIETARY fats; ADIPOSE tissues; DISEASE complications
- Publication
Nutrients, 2024, Vol 16, Issue 3, p367
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu16030367