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- Title
Maternal Death Model Decreases the Expression of BDNF in Rattus Norvegicus Newborns’ Cerebrum and Cerebellum.
- Authors
Apsari, Duhita Dyah; Joewono, Hermanto Tri; Widjiati
- Abstract
Context: Maternal death occured in pregnancy period up to 42 days after giving birth. Maternal death could cause early life stress in newborns which activated HPA axis and glucocorticoid secretion as stress hormone marker. The developing brain was very sensitive to the initial exposure to stressors that would affected the Brain Derived Neurotrophic Factor (BDNF) expression, which was one of the most important endogenous mediators of stress responses in the brain. This study aimed to analyze BDNF expression in the cerebrum and cerebellum of Rattus norvegicus newborn with maternal death model. The control group (K1) consisted of newborns Rattus norvegicus which were not separated from the mother until 3 days old and the treatment group (K2) is maternal death model consisted of newborns Rattus norvegicus which were separated immediately from the mother after birth until 3 days old and fed with animal milk as a substitute nutrient. After 3 days treatments, 3 newborns with heaviest, medium, and lowest weights were taken from each mother to sacrifice. The BDNF expression examination was carried out on cerebrum and cerebellum by imunohistochemical method. The results showed that the mean BDNF expression in the cerebrum and cerebellum of 3 days old Rattus norvegicus with maternal death model which separated from the mother were lower than the mean BDNF expression of control group though there were no significant different based on statistical analysis.
- Subjects
K2 (Pakistan : Mountain); RATTUS norvegicus; BRAIN; CEREBELLUM; MOTHERS; MILK substitutes
- Publication
Indian Journal of Public Health Research & Development, 2020, Vol 11, Issue 3, p1484
- ISSN
0976-0245
- Publication type
Article