We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Improved Activity of Rifampicin Against Biofilms of Staphylococcus aureus by Multicomponent Complexation.
- Authors
Dan Córdoba, Antonella V.; Aiassa, Virginia; Longhi, Marcela R.; Quevedo, Mario A.; Zoppi, Ariana
- Abstract
The aim of this study was to evaluate a multicomponent complex (MC) between rifampicin (RIF), β-cyclodextrin (β-CD), and selected amino acids to enhance the solubility and antibiofilm activity of RIF. After performing phase-solubility studies that demonstrated a considerable increase in the solubility of RIF for the MC, the corresponding solid system was prepared by a freeze-drying method. Characterization of the MC was performed by Fourier transform-infrared spectroscopy, thermal analysis, powder X-ray diffraction, and scanning electron microscopy. Structural analyses evidenced molecular interactions between the components, resulting in a MC with amorphous solid features. Structural studies involving both experimental (i.e., 1H NMR) and theoretical (i.e., molecular modeling) methodologies demonstrated the inclusion of the RIF piperazine ring in the β-CD cavity. The bioactivity of the MC measured against biofilms of Staphylococcus aureus showed a significant reduction in the metabolic activity of the bacterium. Overall, the studied MC exhibited promising properties for the development of pharmaceutical formulations to treat bacterial infections.
- Publication
AAPS PharmSciTech, 2020, Vol 21, Issue 5, pN.PAG
- ISSN
1530-9932
- Publication type
Article
- DOI
10.1208/s12249-020-01706-z